The 3Rs.

SiPerLab: A major advantage for the 3Rs

The implementation of surgery at the pharmacological study site is a significant step forward for animal welfare for the following reasons:

• Eliminating the need to transport operated animals from one site to another: This practice considerably reduces the stress generated by moving animals, as well as the need for an acclimatization period when they arrive at the site of use. By avoiding transport, catecholamine levels in animal models can return to basal levels more quickly.

• Preserving animal model functionality: We know that transporting operated animals can have a detrimental impact on the permeability and signaling of the models used. By performing surgery on site, these transport-related problems are avoided, thus preserving the integrity of the models. As a result, by having high-quality functional models, the need to operate on other animals is reduced.

• Maintaining a stable, familiar environment: Animals remain in a known, stable environment throughout the study. This enables them to be included earlier in the studies, prolonging their use and potentially reducing the need for additional animals.

• Clinical monitoring by the same operators: Animals benefit from clinical monitoring by the same operators throughout their use.
• This continuity helps to standardize observations and animal care.

In short, on-site surgery is a major asset for the 3Rs (Replace, Reduce, Refine) by improving the well-being of animals used in pharmacological studies. By eliminating the need to transport operated animals, preserving model functionality, providing a stable environment and ensuring consistent clinical follow-up
, SiPerLab makes it possible to potentially reduce the number of animals needed while improving their overall well-being.